How do reactions happen in humans




















Enzymes Most biochemical reactions in organisms need help in order to take place. This graph shows what happens when glucose combines with oxygen. An enzyme speeds up the reaction by lowering the activation energy. Compare the activation energy needed with and without the enzyme. How Well Enzymes Work Enzymes are involved in most biochemical reactions, and they do their jobs extremely well.

Enzyme-Deficiency Disorders There are hundreds of known inherited metabolic disorders in humans. Then, the enzyme converts the substrate into the product C by breaking or making bonds between the atoms of the substrate. Feature: Reliable Sources The most common of all known enzyme-deficiency disorders is glucosephosphate-dehydrogenase, or G6PD, deficiency.

Choose one of the following topics about G6PD deficiency: genetic basis signs and symptoms diagnosis and treatment worldwide distribution For the topic, you chose, go online to learn more about it. Review What are biochemical reactions? Define metabolism. Compare and contrast catabolic and anabolic reactions.

Explain the role of enzymes in biochemical reactions. What are enzyme-deficiency disorders? True or False. Metabolism is one specific type of catabolism. Biochemical reactions include catabolic and anabolic reactions. Explain why the relatively low temperature of living things, as well as the low concentration of reactants, would cause biochemical reactions to occur very slowly in the body without enzymes.

Answer the following questions about what happens after you eat a sandwich. Pieces of the sandwich go into your stomach, where there are digestive enzymes that break down the food.

Sodium and chloride ions, for example, are the reactants in the production of table salt. The one or more substances produced by a chemical reaction are called the product. In chemical reactions, the components of the reactants—the elements involved and the number of atoms of each—are all present in the product s. Similarly, there is nothing present in the products that are not present in the reactants.

This is because chemical reactions are governed by the law of conservation of mass, which states that matter cannot be created or destroyed in a chemical reaction. As in math, chemical equations proceed from left to right, but instead of an equal sign, they employ an arrow or arrows indicating the direction in which the chemical reaction proceeds. For example, the chemical reaction in which one atom of nitrogen and three atoms of hydrogen produce ammonia would be written as.

Correspondingly, the breakdown of ammonia into its components would be written as. Notice that, in the first example, a nitrogen N atom and three hydrogen H atoms bond to form a compound. Such reactions are referred to as synthesis reactions. A synthesis reaction is a chemical reaction that results in the synthesis joining of components that were formerly separate [link] a.

Again, nitrogen and hydrogen are reactants in a synthesis reaction that yields ammonia as the product. The general equation for a synthesis reaction is. In the second example, ammonia is catabolized into its smaller components, and the potential energy that had been stored in its bonds is released. Such reactions are referred to as decomposition reactions. The general equation for a decomposition reaction is:. An exchange reaction is a chemical reaction in which both synthesis and decomposition occur, chemical bonds are both formed and broken, and chemical energy is absorbed, stored, and released see [link] c.

The simplest form of an exchange reaction might be:. Notice that, to produce these products, B and C had to break apart in a decomposition reaction, whereas A and B had to bond in a synthesis reaction. A more complex exchange reaction might be:.

Another example might be:. In theory, any chemical reaction can proceed in either direction under the right conditions.

Reactants may synthesize into a product that is later decomposed. Reversibility is also a quality of exchange reactions. For instance, could then reverse to. This reversibility of a chemical reaction is indicated with a double arrow:. Still, in the human body, many chemical reactions do proceed in a predictable direction, either one way or the other.

You can think of this more predictable path as the path of least resistance because, typically, the alternate direction requires more energy. If you pour vinegar into baking soda, the reaction is instantaneous; the concoction will bubble and fizz. But many chemical reactions take time.

A variety of factors influence the rate of chemical reactions. This section, however, will consider only the most important in human functioning. If chemical reactions are to occur quickly, the atoms in the reactants have to have easy access to one another. The kinetic energy of subatomic particles increases in response to increases in thermal energy. The higher the temperature, the faster the particles move, and the more likely they are to come in contact and react.

But as more and more people get up to dance—especially if the music is fast—collisions are likely to occur. It is the same with chemical reactions: the more particles present within a given space, the more likely those particles are to bump into one another. This means that chemists can speed up chemical reactions not only by increasing the concentration of particles—the number of particles in the space—but also by decreasing the volume of the space, which would correspondingly increase the pressure.

If there were dancers in that club, and the manager abruptly moved the party to a room half the size, the concentration of the dancers would double in the new space, and the likelihood of collisions would increase accordingly. For two chemicals in nature to react with each other they first have to come into contact, and this occurs through random collisions. Because heat helps increase the kinetic energy of atoms, ions, and molecules, it promotes their collision.

But in the body, extremely high heat—such as a very high fever—can damage body cells and be life-threatening. On the other hand, normal body temperature is not high enough to promote the chemical reactions that sustain life. That is where catalysts come in. In chemistry, a catalyst is a substance that increases the rate of a chemical reaction without itself undergoing any change. You can think of a catalyst as a chemical change agent.

They help increase the rate and force at which atoms, ions, and molecules collide, thereby increasing the probability that their valence shell electrons will interact. The most important catalysts in the human body are enzymes.

An enzyme is a catalyst composed of protein or ribonucleic acid RNA , both of which will be discussed later in this chapter. Like all catalysts, enzymes work by lowering the level of energy that needs to be invested in a chemical reaction. Once those bonds are broken, new arrangements can form.

Without an enzyme to act as a catalyst, a much larger investment of energy is needed to ignite a chemical reaction Figure 2. Figure 2. Enzymes decrease the activation energy required for a given chemical reaction to occur. They assist, for example, with the breakdown of food and its conversion to energy. In fact, most of the chemical reactions in the body are facilitated by enzymes. The number of atoms before and after the chemical change is the same but the number of molecules will change.

Although many chemical reactions proceed quickly, small, slow changes such as rusting or biological processes can take place over much longer periods of time. Chemical reactions are reversible a fact often omitted in many science texts but in practice most differ from other changes children observe, such as melting, by being very difficult to reverse. Humans use chemical reactions to produce a wide range of useful materials; the breakdown of waste materials also involves chemical reactions that occur naturally in the environment.

For some human made wastes, there are no such reactions and they cause problems as a result. In teaching about chemical reactions at this level the emphasis should be on improving student understanding of the importance of chemical reactions in our lives in producing many of the things we take for granted as well as improving their recognition and understanding of what is involved in a chemical change.

It is not necessary at this stage to talk about particles such as atoms or molecules or chemical bonds. In learning about chemical reactions students will need to describe various substances, which at this level will be materials they are familiar with the kitchen and changes involving cooking are very good starting points. They will need to be able to identify changes in these substances with the purpose of eventually recognising when new chemicals have been produced i.

As mentioned above, this is can be difficult as students often fail to see the difference between an egg white going through a change from liquid to solid as it is cooked and changes such as melting chocolate or boiling water which do not involve chemical change. Teaching will need to be focused on what happens when new substances are formed.

These ideas are also explored in the focus idea Problems with classifying. Environmental effects of chemical reactions can also be considered, for example how we dispose of some chemicals once they are produced, in forms such as plastic bags. At this stage it is important that students are encouraged to put up their ideas and discuss them in small groups. All alternatives should be considered with no resolution at this stage.

A starting activity could be observing the burning of a candle and discussing the changes that take place.



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