What is tribulus extract

Diruetics : Tribulus may increase the effects of other diuretic drugs 7. Antihypertensive drugs : Tribulus has angiotensin converting enzyme ACE -inhibition activity and therefore, may have an additional hypotensive effect 2 3. Antidiabetics : Tribulus may have additive hypoglycemic effects 8. Clopidogrel : May increase the risk of blood clots. Stent thrombosis has been reported in patients following concurrent use of clopidogrel and an herbal formula containing tribulus P-glycoprotein P-gp substrate drugs : In vitro, saponins and phenolic compounds from Tribulus terrestris has been shown to inhibit P-gp activity.

This may increase the risks of adverse effect of substrate drugs Herb Lab Interactions. Significant elevations in serum aminotransferases and creatinine 47 , and mildly elevated alkaline phosphatase as well as aspartate and alanine aminotransferases 27 have been reported. The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments.

Ann N Y Acad Sci. Jan ; Life Sci. Oct 24 ;73 23 Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats. J Ethnopharmacol.

Apr 6 ; 3 Evaluation of natural products on inhibition of inducible cyclooxygenase COX-2 and nitric oxide synthase iNOS in cultured mouse macrophage cells. Nov ;83 Effect of aqueous extract of Tribulus terrestris on oxalate-induced oxidative stress in rats.

Indian J Nephrol. Jul ;21 3 The protective effect of Tribulus terrestris in diabetes. Nov ; Tribulus terrestris : preliminary study of its diuretic and contractile effects and comparison with Zea mays. Apr ;85 Hypoglycemic and hypolipidemic effects of alcoholic extract of Tribulus alatus in streptozotocin-induced diabetic rats: a comparative study with T.

Indian J Exp Biol. Sep ;45 9 Antibacterial and antifungal activities of different parts of Tribulus terrestris L. J Zhejiang Univ Sci B.

Feb ;9 2 In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. Biol Pharm Bull. Dec ;28 12 Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators. In Vivo. Jul-Aug ;23 4 Aqueous extract of Tribulus terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-kappaB signaling in liver cancer cells.

Jun 14 ; 1 Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats. Jan 8 ; 1 Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. J Pharmacol Pharmacother. Jan ;3 1 Saponins from Tribulus terrestris L are less toxic for normal human fibroblasts than for many cancer lines: influence on apoptosis and proliferation.

Exp Biol Med Maywood. Jan ; 1 Short term impact of Tribulus terrestris intake on doping control analysis of endogenous steroids.

Forensic Sci Int. Jun 10 ; 1 :e Tribulus terrestris -induced severe nephrotoxicity in a young healthy male. Nephrol Dial Transplant. Nov ;25 11 Bourke CA. Abnormal turning behaviour, GABAergic inhibition and the degeneration of astrocytes in ovine Tribulus terrestris motor neuron disease. Aust Vet J. Jan-Feb ;84 Chemopreventive potential of Tribulus terrestris against 7, dimethylbenz a anthracene induced skin papillomagenesis in mice.

Asian Pac J Cancer Prev. Apr-Jun ;7 2 Alternative treatment of ovarian cysts with Tribulus terrestris extract: a rat model. Reprod Domest Anim. Feb ;47 1 :e Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata.

Urol Res. May ;33 2 Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris. Int Braz J Urol. Jul-Aug ;36 4 ; discussion , Turk Kardiyol Dern Ars. Apr ;40 3 The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players.

J Strength Cond Res. May ;21 2 A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J Diet Suppl. One study examined the effects of taking 1, mg of Tribulus terrestris per day in 98 women with type 2 diabetes.

After three months, women taking the supplement experienced lower blood sugar and cholesterol levels, compared to those who took a placebo 5. Animal studies have also shown that Tribulus terrestris may reduce blood sugar levels , help protect against blood vessel damage and help prevent increases in blood cholesterol 6 , 7.

While these findings appear promising, more research is needed before this plant can be recommended for these health benefits. Summary: Preliminary evidence shows that Tribulus terrestris may improve blood sugar control and cholesterol in people with diabetes. However, research in humans is limited. A quick online search for Tribulus terrestris supplements shows that many products made with the plant are focused on boosting testosterone.

The studies lasted from 2—90 days, and the participants included healthy people and those experiencing sexual problems. The researchers found that this supplement did not increase testosterone 4. Other researchers found that Tribulus terrestris may increase testosterone in some animal studies, but that this result is not usually seen in humans 8. Summary: Despite marketing claims, Tribulus terrestris does not appear to increase testosterone in humans.

This conclusion is based on studies in men and women of various health statuses and ages. Even though this supplement may not increase testosterone, it may boost libido. Other studies have also reported that supplements containing the herb enhanced sexual desire, arousal and satisfaction in women with low libido Some research shows that taking mg of this supplement per day may not effectively treat erectile dysfunction However, other reports showed significant improvements in erections and sexual satisfaction with a dose of 1, mg per day While it seems that Tribulus terrestris may improve libido in women and men, more research is needed to clarify the extent of the sexual effects of this supplement.

Summary: Research has found that Tribulus terrestris may improve libido in women and men with reduced sex drives. Studies on the herb as a treatment for erectile dysfunction have shown mixed results, with higher doses appearing to be more beneficial.

Active individuals frequently take Tribulus terrestris supplements to improve their body composition by increasing muscle or decreasing fat In fact, research is also very limited on whether the plant improves body composition or performance in active individuals and athletes.

One study examined how Tribulus terrestris supplements affected the performance of elite male rugby players. The men took the supplements during five weeks of weight training. However, by the end of the study, there were no differences in improvements in strength or body composition between the supplement and placebo groups Another study found that eight weeks of taking this supplement with an exercise program did not improve body composition, strength or muscle endurance more than a placebo Unfortunately, no research is available on the effects of Tribulus terrestris in exercising women.

Summary: Tribulus terrestris does not seem to increase muscle, decrease fat or improve exercise performance more than a placebo. In addition to the potential health effects discussed already, Tribulus terrestris may have several other effects in the body:.

However, almost all of these effects have only been studied in animals or test tubes, and even then, the evidence is very limited 3. Much more research, both in animals and humans, is needed to find out whether Tribulus terrestris has these effects. Summary: Although many people speculate about the health effects of Tribulus terrestris , there is very limited support for many of these claims.

Much of the existing research has been conducted in animals or test tubes, not humans. Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. Tribulus Tribulus terrestris is a small, flowering plant also known as puncture vine and goat's head.

The plant yields a fruit that is covered with spines. The fruit, leaf, and root are used as medicine to treat a number of conditions, most notably sexual dysfunction. Tribulus has long been used in traditional Chinese medicine, as well as in ayurveda to enhance athletic performance or increase libido. Tribulus is also said to raise your levels of certain hormones, including testosterone and estrogen, and is found in supplements claiming to increase testosterone levels.

In addition, tribulus is purported to help a variety of health issues such as high blood pressure, high cholesterol, kidney stones, erectile dysfunction, sexual dysfunction, and act as a diuretic. Here's a look at selected findings from the available research on tribulus. Dietary supplements containing tribulus are often marketed for their potential to increase testosterone levels and, in turn, build muscle mass and boost strength. However, a report published in the Journal of Dietary Supplements in states that such marketing claims are unsubstantiated.

In the analysis of 11 previously published clinical trials, the report's authors determined that a testosterone-increasing effect was found only when tribulus was consumed by way of supplements containing a combination of substances.

Tribulus may help treat erectile dysfunction, according to a study published in Maturitas in In testing the effects of 12 weeks of a tribulus extract on men with mild or moderate erectile dysfunction, researchers found that those who took tribulus had a significant improvement in sexual function including erectile dysfunction. In a report published in Drugs in , researchers sized up previously published clinical trials. According to the report's authors, their analysis demonstrated that " T.

Additionally, a small study published in Gynecological Endocrinology in indicates that tribulus may help treat sexual dysfunction in women. For the study, 40 women with diminished libido were treated with tribulus or a placebo.

At the study's end, those who received tribulus had increased testosterone levels and experienced a significant improvement in factors such as desire, arousal, pain, and satisfaction. Based on existing evidence some practitioners recommend an herbal preparation of tribulus to support hormonal and sexual function of their patients.

Tribulus may fight diabetes, suggests a small study published in the Journal of Evidence-Based Complementary and Alternative Medicine in Blood glucose, total cholesterol, and LDL cholesterol were significantly reduced compared with the placebo.

There was no significant effect observed in triglyceride and HDL cholesterol levels. Since so few studies have tested tribulus' health effects in humans, little is known about the safety of long-term use of this herb. However, there's some concern that tribulus may trigger side effects such as increased heart rate and restlessness.

In addition, some research indicates that tribulus may increase prostate weight. Men with conditions such as benign prostatic hypertrophy or prostate cancer should avoid the use of this herb.

Because tribulus may reduce blood sugar levels, taking the herb in combination with diabetes medication may cause your blood sugar to become dangerously low. According to a case report, a year old man was diagnosed with priapism a prolonged and painful erection of the penis after consuming an herbal supplement containing tribulus.

Dietary supplements are largely unregulated, and in some cases may contain substances or ingredients that are not on the label. The risk may be higher for supplements marketed for athletic performance, which may be contaminated with anabolic steroids and other substances, resulting in unintentional doping.

Various doses of tribulus have been used in studies investigating the plant's health benefits.