Where to buy igob131 extract

How It Works. Purported Uses. Weight loss Although clinical trials have benefit, meta-analyses have determined that the evidence is insufficient. Lower cholesterol Clinical studies have shown that use of the seed extract leads to a reduction in cholesterol levels along with weight loss.

Due to the small sample size, more studies are still needed. Diarrhea, colic, dysentery Although used traditionally in Africa, scientific data are lacking to support these claims.

Pain The pain-relieving components of African mango bark are not yet known, but a study demonstrated that both water and ethanol extracts produce pain-relieving effects, with the water extract having stronger effects. Blood glucose A clinical trial on the seed extract from African mango shows a reduction in blood glucose levels in participants.

However, this was a small study and more research is needed. Infection Laboratory studies showed that the alcohol extract of African mango has antimicrobial effects against bacteria and fungi. Its usage in humans has not been evaluated. Do Not Take If. You are taking antidiabetic medications: Rat studies suggest African mango may further lower blood glucose levels.

Side Effects. Gas Headaches Difficulty sleeping. For Healthcare Professionals. Brand Name. Scientific Name. Clinical Summary. Food Sources. The fruit of African mango is consumed as food in West and Central Africa. Mechanism of Action. Adverse Reactions.

Gas, headaches, and difficulty sleeping 4 A manufacturer-sponsored subchronic toxicity study suggests that an African mango kernel extract IGOB does not cause adverse effects in animals Herb-Drug Interactions. Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis Ixonanthaceae.

J Ethnopharmacol. Oct 8 ; 1 Analgesic effect of Irvingia gabonensis stem bark extract. Feb ;45 2 The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon. Lipids Health Dis. IGOB, a novel seed extract of the West African plant Irvingia gabonensis , significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation.

Hypoglycaemic effect of the methanol extract of Irvingia gabonensis seeds on streptozotocin diabetic rats. Irvingia gabonensis fat: nutritional properties and effect of increasing amounts on the growth and lipid metabolism of young rats wistar sp. Inhibition of Irvingia gabonensis seed extract OB on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene. Ross SM. African mango IGOB : a proprietary seed extract of Irvingia gabonensis is found to be effective in reducing body weight and improving metabolic parameters in overweight humans.

Holist Nurs Pract. Jul-Aug ;25 4 Akubor PI. The suitability of African bush mango juice for wine production. Plant Foods Hum Nutr. Apr ;49 3 Food Chem Toxicol. May ;50 5 Sun J1, Chen P. Ultra high-performance liquid chromatography with high-resolution mass spectrometry analysis of African mango Irvingia gabonensis seeds, extract, and related dietary supplements. J Agric Food Chem. Anthelmintic potential of three plants used in Nigerian ethnoveterinary medicine. Pharm Biol. The efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials.

J Diet Suppl. J Am Coll Nutr. This is the first double blind randomized placebo controlled clinical trial regarding the anti-obesity and lipid profile modulating effects of an Irvingia gabonensis extract.

The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies.

Irvingia gabonensis extract may prove to be a useful tool in dealing with the emerging global epidemics of obesity, hyperlipidemia, insulin resistance, and their co-morbid conditions.

Trial registration: ClinicalTrials. Abstract Background: A recent in vitro study indicates that IGOB, a novel seed extract of the traditional West African food plant Irvingia gabonensis, favorably impacts adipogenesis through a variety of critical metabolic pathways including PPAR gamma, leptin, adiponectin, and glycerol-3 phosphate dehydrogenase.